I heard R. C. Sproul explain it this way: He said that apart from God there is no reason for human significance and no grounds for self-worth. Consider the alternative. If you don't believe in God, then you don’t have any reason for being here. You must believe that you are simply the product of impersonal time plus chance. And when you die, you must believe that you simply cease to exist and vanish into eternal nothingness. In short, if you leave God out, what you are left with is this: You didn't come from anywhere and you aren’t going anywhere after you die. This is the humanist dilemma. They say, “You come from nothing and you're going to nothing, but in between you have great significance.” It doesn't make sense at all.