There are, of course, those whom God has determined that He would never give new life to. Those who have committed the unpardonable sin, blasphemy against the Holy Spirit (Matthew 12:31), will not be regenerated. Those who have trampled under foot the blood of Christ (Hebrews 10:29), will not be regenerated. Those who have committed the sin unto death (I John 5:15-16) will not be regenerated. I do not pretend to know whether this is one, two or three distinct groups. I do know this – that those who fall under these texts do not come equipped with a signed affidavit letting us know for certain that they are guilty of this sin. As such, I don’t believe we can single out real flesh and blood people and determine – “That one is beyond redemption.”
R.C. Sproul Jr.