For us, we’re trying to abandon sin and embrace holiness. For [Jesus], He was being tempted [in the Garden] to abandon holiness and embrace sin bearing. It’s just the opposite. This is incomprehensible to Him. This is repulsive to Him. This is foreign to Him; He’s not like us. He’s not fighting against sinful impulses to be holy. He’s fighting against holy impulses to be made sin.
John MacArthur