So what did the Holy Spirit intend by His command not to be bound together with unbelievers? Bound together translates a participial form of the verb heterozugeo, which means, “to be unequally yoked.” Paul drew his analogy from Deuteronomy 22:10, where the Mosaic Law commanded the Israelites, “You shall not plow with an ox and a donkey together.” Those two animals do not have the same nature, gait, or strength. Therefore it would be impossible for such a mismatched pair to plow together effectively. Nothing in the context would lead to the idea that he is referring to earthy issues of human endeavors. In Paul’s analogy, believers and unbelievers are two different breeds and cannot work together in the spiritual realm. He called for separation in matters of the work of God, since such cooperation for spiritual benefit is impossible. The false teachers were eager to blend the people of God with the pagan worshipers, because that hinders the gospel. That is what this text forbids.
John MacArthur

Bible – English_World – Philippians Chapter 4:1-23.

Index: World English Bible

 

Philippians 4

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4:1 Therefore, my brothers, beloved and longed for, my joy and crown, so stand firm in the Lord, my beloved.

4:2 I exhort Euodia, and I exhort Syntyche, to think the same way in the Lord.

4:3 Yes, I beg you also, true yoke-fellow, help these women, for they labored with me in the Gospel, with Clement also, and the rest of my fellow workers, whose names are in the book of life.

4:4 Rejoice in the Lord always! Again I will say, Rejoice!

4:5 Let your gentleness be known to all men. The Lord is at hand.

4:6 In nothing be anxious, but in everything, by prayer and petition with thanksgiving, let your requests be made known to God.

4:7 And the peace of God, which surpasses all understanding, will guard your hearts and your thoughts in Christ Jesus.

4:8 Finally, brothers, whatever things are true, whatever things are honorable, whatever things are just, whatever things are pure, whatever things are lovely, whatever things are of good report; if there is any virtue, and if there is any praise, think about these things.

4:9 The things which you learned, received, heard, and saw in me: do these things, and the God of peace will be with you.

4:10 But I rejoice in the Lord greatly, that now at length you have revived your thought for me; in which you did indeed take thought, but you lacked opportunity.

4:11 Not that I speak in respect to lack, for I have learned in whatever state I am, to be content in it.

4:12 I know how to be humbled, and I know also how to abound. In everything and in all things I have learned the secret both to be filled and to be hungry, both to abound and to be in need.

4:13 I can do all things through Christ, who strengthens me.

4:14 However you did well that you shared in my affliction.

4:15 You yourselves also know, you Philippians, that in the beginning of the Gospel, when I departed from Macedonia, no assembly shared with me in the matter of giving and receiving but you only.

4:16 For even in Thessalonica you sent once and again to my need.

4:17 Not that I seek for the gift, but I seek for the fruit that increases to your account.

4:18 But I have all things, and abound. I am filled, having received from Epaphroditus the things that came from you, a sweet-smelling fragrance, an acceptable and well-pleasing sacrifice to God.

4:19 My God will supply every need of yours according to his riches in glory in Christ Jesus.

4:20 Now to our God and Father be the glory forever and ever! Amen.

4:21 Greet every saint in Christ Jesus. The brothers who are with me greet you.

4:22 All the saints greet you, especially those who are of Caesar’s household.

4:23 The grace of the Lord Jesus Christ be with you all. Amen.